Welcome to the Biotage Sample Preparation Blog

      Jeremy Smith


      Recent Posts

      Programming?  Two Independent Evaporation Methods? Multiple Plate Configurations? We Certainly Can!

      February 22, 2022 at 6:00 PM / by Jeremy Smith posted in Solvents, evaporation systems, TurboVap, 96-well plates, vials

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      This concept seems simple today, but traditional nitrogen evaporators haven’t been overhauled for many years. Even in our lab we were not able to store evaporation methods… until now!

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      Simplifying Solvent Evaporation for Sample Prep with Next Generation Systems

      February 4, 2022 at 10:17 PM / by Jeremy Smith posted in solvent evaporation, evaporation systems, TurboVap, 96-well plates, vials

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      One of the hottest, yet most neglected topics in sample preparation is evaporation. Most chromatographic methods require some form of sample cleanup prior to injection into a HPLC or GC system to prevent clogging or undesired interferences. Many users opt to skip evaporation and perform a direct injection of the purified sample, but this is not always feasible.

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      Setting yourself up for Success

      May 27, 2021 at 8:36 AM / by Jeremy Smith posted in LC-MS, GC-MS, SPE, Positive Pressure, High Throughput, Low Volume Extractions, mass spec

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      Developing a new sample prep method should be systematic to ensure ruggedness, and can be done quickly with the right tools. The days of using a vacuum manifold are gone, along with the variability and long extraction times incurred. Today’s options provide an array of positive pressure systems that process a wide range of sample matrices, varying in viscosities.

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      Is Sample Prep the only thing to consider for successful analyses?

      September 25, 2020 at 9:04 AM / by Jeremy Smith posted in Sample preparation

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      We’ve all been there. We prepare a batch of samples to analyze, prime our systems, warm up the detector, and within 2-3 injections we receive an error message stating that an integral component has failed for one reason or another. This can be a dreadful experience, especially for a routine production laboratory. 

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      There and Square Again: A Frit Coverage Tale

      August 20, 2020 at 8:00 AM / by Jeremy Smith posted in Troubleshooting and Optimization, Loading Techniques, SLE Supported Liquid Extraction, Sample preparation

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      Have you ever encountered problems loading your samples onto an SPE or SLE plate?  Aside from sample viscosity or cartridge blockages, a good troubleshooting step to start with is ensuring that you are achieving complete frit coverage on the load.

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