Why is pH adjustment important for sample prep methods?
June 30, 2020 at 2:08 PM / by Stephanie J. Marin, Ph.D.
How to determine recovery and matrix effects for your analytical assay
June 30, 2020 at 10:50 AM / by Dan Menasco
For many of us developing an analytical assay requires numerous experiments in addition to lots of data review, and yet despite the feeling of confidence in our success, how reliable is our assay really? How do we measure reliability of our assay?
What’s the Best Way to do Supported Liquid Extraction?
June 23, 2020 at 4:09 PM / by Stephanie J. Marin, Ph.D.
Supported Liquid Extraction (SLE) is a sample preparation technique that has been in use for over ten years now, but many analytical chemists don’t know about, or understand the best way to do an SLE extraction. In this post, I’m going to talk about how SLE works and the proper way to do an SLE extraction for sample clean up.
Easy protocol to develop your Supported Liquid Extraction method
June 23, 2020 at 4:00 PM / by Bruce Kempf
Taking the time to develop a Supported Liquid Extraction (SLE) method using easy steps can save you hours or days of headaches down the road as well as giving you the peace of mind that you’re getting the best recoveries possible.
In-well hydrolysis plates: What are they and do they really work?
June 16, 2020 at 2:23 PM / by Jillian Neifeld, MS
One of the key features of the so called "in-well hydrolysis" is that it can be a time saver for high throughput labs, which makes it look very appealing. In this blog post, I will be discussing some of the advantages of using an in-well hydrolysis plate and some of the results that I’ve gotten when compared to an out-of-well hydrolysis plate.
Urine hydrolysis: how did I choose which enzyme to use?
June 16, 2020 at 2:15 PM / by Jillian Neifeld, MS
Urine hydrolysis is a part of sample preparation that we do to eliminate glucuronides before urine analysis. So first, what are glucuronides? And why do we want to get rid of them? In this post, I’ll tell you about my experience with urine hydrolysis and my success (or lack of success) when using different enzymes.
What is the Role of LogP in Sample Prep Methods?
June 10, 2020 at 3:30 PM / by Stephanie J. Marin, Ph.D.