Smarter Sample Prep for Therapeutic Drug Research


A Complete Guide to Bioanalytical Sample Preparation

You analyze a lot of biological samples. You deliver accurate, reliable data, consistently. You use sophisticated, high-end analytical techniques such as LC-MS/MS or GC-MS. And the pressure is always there to do it faster, with greater sensitivity and, if possible, at lower cost. Sample preparation can be critical for success.

Learn more here on how to choose the right approach for your samples.

Bioanalytical Sample Prep

Application Note 758

Trending Application Notes

Extraction of a Range of Immunosuppressants from Whole Blood Using ISOLUTE® SLE+ Prior to LC-MS/MS Analysis

This application note describes the extraction of sirolimus, tacrolimus, everolimus, cyclosporin A from whole blood samples using supported liquid extraction prior to LC-MS/MS analysis. Read More


Trending Application Notes

Extraction of a Range of Acidic, Basic and Neutral Drugs from Plasma Using ISOLUTE ® PLD+ Plates Prior to LC MS/MS Analysis

The protein and phospholipid removal obtained using ISOLUTE® PLD+ Protein and Phospholipid Removal Plates provided clean extracts with very low matrix effects. Residual phospholipids were investigated to provide an indication of extract cleanliness. Read More

Application Note 830

Application Note 887

Trending Application Notes

Extraction of Desmopressin from Serum Using

Desmopressin is an antidiuretic hormone and a synthetic vasopressin analogue. Desmopressin is clinically used to treat bedwetting (nocturnal enuresis), diabetes insipidus and may also be used for clotting disorders. The method described in this application achieves high reproducible extraction recoveries of desmopressin peptide from serum while minimizing co-extractable material in the form of proteins, lipids and phospholipids. Extraction from serum was performed using EVOLUTE® EXPRESS WCX 96-well plates. Read More

Highlighted Products

ISOLUTE® SLE+ Supported Liquid Extraction

ISOLUTE® SLE+ Supported Liquid Extraction plates and columns are designed to provide stress free extraction of analytes from biological fluids, with high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple. Read More



Highlighted Products

ISOLUTE® PLD+ Protein & Phospholipid Removal Products

Effortlessly Enhance Analyte Sensitivity

Very effective but extremely simple sample clean-up for LC-MS/MS analysis. Requiring next to no method development, ISOLUTE PLD+ can be integrated quickly and easily into routine workflow, increasing productivity and reducing instrument downtime. Read More

Clinical Applications Compendium

Whether you need targeted methods for analytes such as Vitamin D metabolites in serum, or methods suitable for extraction of a wide panel of drugs and metabolites from urine, sample preparation before analysis is essential. This compendium highlights a selection of clinical sample preparation applications from Biotage.




Clinical Applications Compendium