Smarter Sample Prep for Forensic Drugs of Abuse

Bioanalytical Sample Prep


A Complete Guide to Bioanalytical Sample Preparation

You analyze a lot of biological samples. You deliver accurate, reliable data, consistently. You use sophisticated, high-end analytical techniques such as LC-MS/MS or GC-MS. And the pressure is always there to do it faster, with greater sensitivity and, if possible, at lower cost. Sample preparation can be critical for success.

Learn more here on how to choose the right approach for your samples.

Smarter Sample Prep for THC Analysis

Blood, Urine and Oral Fluid

Biotage provides simple and effective sample prep protocols for cleanup of blood, urine, and oral fluid samples that produce reliable results, and are automation compatible. Recreational marijuana use is currently legal in many regions around the world. Because of this, it is increasingly important for laboratories to develop accurate testing methods for THC and its related compounds in biological matrices.       Read More

Marijuana Leaf
Application Note 932

Trending Application Notes

Sample Preparation Techniques for Synthetic Benzos

Synthetic benzodiazepines are becoming more abused and are considered “legal highs”. Many forensic laboratories are finding more and more of these compounds in postmortem and impairment cases. While synthetic benzodiazepine prevalence has not been widely broadcast as it is overshadowed by the opioid epidemic, this drug class is now the fourth most commonly identified illegal synthetic
drug class. Read More

Trending Application Notes

Sample Preparation for Fentanyl Analogs in Whole Blood

Fentanyl and its analogs are part of the growing opioid crisis in the United States. According to the latest data from the National Survey on Drug Use and Health, more than 2.1 million Americans struggle with an opioid use disorder for either prescription pain relievers or heroin. Read More

Technical Note 546
Oral Fluid White Paper

White Paper

Practical Considerations Using Quantisal® Oral Fluid Collection Devices

Oral fluid is a popular matrix for drugs of abuse testing. It is easy to collect and more difficult to adulterate than urine. A new white paper from Biotage deals with practical considerations using Quantisal® oral fluid collection devices and SPE method development by Polymeric mixed-mode cation exchange.



Highlighted Products

ISOLUTE® SLE+ Supported Liquid Extraction 

ISOLUTE® SLE+ Supported Liquid Extraction plates and columns are designed to provide stress free extraction of analytes from biological fluids, with high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple. Read More


Highlighted Products


EVOLUTE® EXPRESS Sample Preparation products provide robust, reliable SPE, giving ultra-pure extracts and high analyte recoveries. Developed specifically for analyte quantification by LC-MS/MS, EVOLUTE sorbents provide a highly effective solution to the problems of ion suppression and matrix effects. Eliminate conditioning and equilibration with EVOLUTE EXPRESS load-wash-elute SPE. Read More

Highlighted Video

ISOLUTE® HYDRO DME+ Dual Mode Extraction Products

The Fast, Affordable Way to Clean up Biological Samples for LC-MS/MS

ISOLUTE® HYDRO DME+ columns and plates provide extremely efficient removal of matrix components and hydrolysis enzyme from urine and other biological fluid samples, using a simple pass through workflow. Read More