Methods for a drug class or one large panel - what's the difference

August 23, 2020 at 8:00 AM / by Stephanie J. Marin, Ph.D. posted in LC-MS, GC-MS, Extraction method optimization, Sample preparation, Method development

Most clinical and forensic labs have a used a traditional approach for drug testing called screen with reflex to confirmation. This involves analyzing samples using an immunoassay technique that identifies a drug class. Positive immunoassay results are then analyzed by a second more specific method, like GC-MS or LC-MS/MS, to identify and quantitate specific drug analytes.

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How does my sample prep change between GC/MS and LC/MS/MS?

July 23, 2020 at 8:00 AM / by Jillian Neifeld, MS posted in LC-MS, GC-MS, Sample preparation

LC/MS/MS seems to be the gold standard in sample analysis nowadays. However, some labs are still analyzing samples using GC/MS. The majority of published peer-reviewed articles are for LC/MS/MS, so those working with GC/MS instrumentation may not know how to change the sample preparation to better fit GC/MS.

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High Quality Sample Prep is Critical in Analytical Labs

February 18, 2020 at 8:19 AM / by Nigel Tooke posted in Automation, SLE Supported Liquid Extraction, SPE solid phase extraction, Quality of Biotage Products, LC-MS, GC-MS

Analytical laboratories using techniques such as LC-MS/MS or GC-MS are continuously searching for ways to increase throughput, reduce turnaround times and lower costs. Sample prep is often an underestimated component in this process, but is a critical step that removes matrix interferences, concentrates samples, and also protects expensive analytical instrumentation.

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