Evaporative crosstalk is contamination that occurs during evaporation of the elution solvent after SLE or SPE extraction. Volatile analytes evaporate, then redistribute in adjacent wells in a 96-well plate. This can generate false positive results and require re-extraction of patient specimens. Addition of HCl in methanol (MeOH) to produce the salt of volatile compounds like sympathomimetic amines is used to control crosstalk. The type of evaporator, conditions and solvents used can all contribute to crosstalk.