Welcome to the Biotage Sample Preparation Blog

      Dilute & shoot ... yourself in the foot

      October 21, 2020 at 8:30 AM / by Simonetta Tumbiolo posted in SLE Supported Liquid Extraction, Sample preparation, Method development, Clinical

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      Urine samples are composed of many interferents which can cause ion-suppression or ion-enhancement when analyzing by mass spec. Build up of these matrix components over multiple sample injections can lead to loss of signal in the mass spec and even unexpected changes in your chromatographic separation. We are going to discuss why not performing adequate sample prep can be detrimental for your analyses.

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      Synthetic Cannabinoids: how to extract them from whole blood?

      August 26, 2020 at 2:41 PM / by Jillian Neifeld, MS posted in SLE Supported Liquid Extraction, Forensic, Clinical, Whole Blood, Cannabinoids

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      Synthetic cannabinoids are some of the most widely abused drugs in the world. They are structurally similar and have similar effects to marijuana but are frequently referred to as “legal highs”. Chemists are constantly changing the structures of these compounds to keep them in a legal state and governments can’t keep up with adding them to scheduled lists. So, how do we analyze for these compounds? How can they be easily extracted from whole blood?

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