A prime objective of bioanalytical sample preparation is to achieve high analyte recovery in low elution volumes, with rapid delivery of clean extracts that support robust high sensitivity analysis to meet goals for detection limits. What's best between conventional solid phase extraction (SPE) and microelution SPE?
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Solid phase extraction (SPE) is frequently used for sample clean up, trace enrichment (pre-concentration of the sample), or a combination of both prior to analysis. But can solid phase extraction be an effective tool when bioanalysis demands higher sensitivity and reproducibility with decreasing sample volumes? In theory, SPE can be used for targeted extractions with ultra-high concentrations. As we will see, putting this into practice requires miniaturization of SPE extraction using sorbent beds with optimal formats that minimize elution volume to maximize detection and quantitation power.
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Highly sensitive techniques such as LC-MS/MS are enabling analytical laboratories to generate more data on more analytes in more samples, in less time, at a lower cost, and using smaller sample volumes. Achieving this performance involves pushing the limits of detection and quantitation with high levels of sensitivity and reproducibility that are only possible with high quality samples.
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Do you have a small to medium size analytical lab and are reaching the limit of what you can achieve with manual sample prep? Perhaps you need more robust sample prep with higher efficiency, less hands-on time, and better control over your samples?
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Meeting throughput- and efficiency targets in the analytical laboratory working in a Good Laboratory Practices (GLP) environment involves a constant hunt for new ways to improve workflows and sample quality.
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Automated sample prep helps your lab to run more smoothly. Sample prep is often seen as a painful process that is time-consuming, laborious, complex, error-prone, and costly. But efficient sample prep is a critical step that is required to supply high performance analytical equipment with the best possible input to routinely generate high quality data output.
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Analytical laboratories using techniques such as LC-MS/MS or GC-MS are continuously searching for ways to increase throughput, reduce turnaround times and lower costs. Sample prep is often an underestimated component in this process, but is a critical step that removes matrix interferences, concentrates samples, and also protects expensive analytical instrumentation.
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