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      Bruce Kempf


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      Extracting both acidic and basic analytes in a single SLE procedure

      August 9, 2020 at 8:00 AM / by Bruce Kempf posted in SLE Supported Liquid Extraction

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      Often the question arises asking how can I extract both acids and bases with the same Supported Liquid Extraction (SLE) procedure. Is this possible? And how?

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      Techniques for disrupting protein binding in sample preparation

      August 2, 2020 at 8:00 AM / by Bruce Kempf posted in SLE Supported Liquid Extraction, SPE solid phase extraction, Sample preparation, Solid-phase extraction, Method development

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      If you are frustrated with low recoveries caused by protein binding during Supported Liquid Extraction (SLE) and Solid Phase Extraction (SPE), this blog post will give you a few tips. Proper sample pre-treatment is the key to solving this issue.

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      Choosing the best Ion Exchange Mode for Solid Phase Extraction

      July 16, 2020 at 8:00 AM / by Bruce Kempf posted in SPE solid phase extraction, Solid-phase extraction, ION exchange, Evolute Express

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      There is often confusion as to how to choose the proper SPE ion exchange media. How do you determine if you should be looking at anion or cation, weak or strong? In this post, I will give some simple guidelines on making the best choice. You will see that ion exchange is all about acids and bases.

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      When should I choose SLE or SPE for sample cleanup?

      July 13, 2020 at 9:21 AM / by Bruce Kempf posted in SLE Supported Liquid Extraction, SPE solid phase extraction

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      When it comes to sample cleanup the question occasionally comes up asking what technique is best for my application: Solid Phase Extraction (SPE) or Supported Liquid Extraction (SLE)? Well, what’s right for you depends on your application and the characteristics of your analytes. This post outlines some of the advantages, disadvantages and limitations of each technique.

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      Easy protocol to develop your Supported Liquid Extraction method

      June 23, 2020 at 4:00 PM / by Bruce Kempf posted in SLE Supported Liquid Extraction, Extraction method optimization

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      Taking the time to develop a Supported Liquid Extraction (SLE) method using  easy steps can save you hours or days of headaches down the road as well as giving you the peace of mind that you’re getting the best recoveries possible.

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