Systematic Sample Preparation Method Development for LC-MS/MS Assays is presented by Biotage as a 4 part training course for laboratories analyzing clinical or forensic specimens using mass spectrometry. It offers a proven, systematic approach to fast and efficient sample preparation method development. The research scientist acquires the knowledge and tools to develop sample preparation methods based on specimen type, compounds of interest and their properties with a minimal number of experiments. The series is presented by Biotage applications and senior applications chemists with many years of practical experience.

Toolbox for Method Development

Wednesday, February 10, 2021 1:30 PM - 2:30 PM EST

Part one is the toolbox for method development and discusses considerations for robust assays, the mechanisms of different sample preparation chemistries, techniques and protocols for different sample preparation techniques, and introduces the Biotage three step process for systematic sample preparation method development.


Blood Assays:

Wednesday, February 17, 2021 at 1:30 PM - 3:00 PM EST

Part two guides the attendee through systematic sample preparation method development for blood. Examples for designing experiments to screen and optimize different sample prep techniques with a minimum number of experiments for serum, plasma and whole blood is presented.


Urine Assays:

Wednesday, February 24, 2021 at 1:30 PM - 2:30 PM EST

Part three discusses sample preparation for urine including considerations for hydrolysis of urine specimens and method development experiments for urine assays by drug class and a multi-class, multi-component panel.


Assays for Alternative Matrices:

Wednesday, March 3, 2021 1:30 PM - 2:30 PM EST

Part four discusses sample preparation method development for alternate matrices with examples for tissue, oral fluid and breast milk.

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